Background: No reports are available on the technical efficiency and therapeutic response of virtual nav-igation (VN)-guided radiofrequency ablation (RFA) for patients with recurrent hepatocellular carcinoma (HCC) after hepatic resection. The aim of this study was to investigate the overall technical performance and outcome of VN-guided RFA in recurrent HCC patients. In addition,a nomogram model was developed to predict the factors influencing the overall survival (OS).Methods: This was a prospective study on 76 recurrent HCC patients who underwent VN-guided RFA be-tween June 2015 and February 2018. The technical feasibility,success,and efficiency,OS,local tumor pro-gression,and complications were evaluated. A multivariate Cox regression analysis was conducted to pre-dict the significant factors,and a nomogram including independent predictive factors was subsequently plotted to predict OS. Results: The technical feasibility,success,and efficiency rates of VN-guided RFA were 86.4％,94.7％,and 97.4％,respectively. The cumulative OS rates at 1-,2-,and 3-year were 88.1％,79.7％,and 71.0％,respec-tively. The cumulative local tumor progression rates at 1-,2-,and 3-year were 5.5％,8.7％,and 14.0％,respectively. In addition,the minor and major complication rates were 5.3％ and 3.9％,respectively. No intervention-related deaths occurred during the follow-up period. The C-index of the OS nomogram in this study was 0.737. Conclusions: VN-guided RFA is an effective therapeutic option in recurrent HCC patients and improves the long-term outcomes especially for the lesions that cannot be detected in the two-dimensional ultra-sound. Besides,the nomogram may be a useful supporting tool in predicting OS to estimate the individual survival probability,optimize treatment options,and facilitate decision-making.