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自 Devrg 从黄花夹竹桃果仁提出了水溶性配糖体 Thevetin,Huseman 及 Konag 发现此配糖体具洋地黄类似作用以后,各国学者相继地进行了一些化学和药理研究。1934年陈克恢氏等从檀香山产黄花夹竹桃果仁分离出三个物质 Thevetin、Ahouain、Kokeilphin。1936年陈克恢氏等及1948年 Gtold分别做了临床试验,证明 Thevetin 疗效如洋地黄,用针剂注射时,发生作用的时间较迅速(六分钟),维持时间短(注射后,只维持二至三小时)。尽管 Thevetin 具有这些优点,但利用它作为强心药仍未能引起各国的普遍重视。目前,在我国缺乏强心类药物的情况下,寻找进口毒毛旋花子素代用品,是十
Since Devrg proposed water-soluble glycosides from H. oleander nectar, Thevetin, Huseman, and Konag found that this glycoside has similar effects to digitalis, and scholars from various countries have conducted some chemical and pharmacological studies one after another. In 1934, Chen Kehui and others isolated three substances, Thevetin, Ahouain, and Kokeilphin, from the nuts of Nerium oleander produced in Honolulu. In 1936, Chen Kehui’s et al. and Gtold’s in 1948 did clinical trials respectively, demonstrating that the efficacy of Thevetin is digitalis. When injected with injections, the action takes more time (six minutes) and the maintenance time is shorter (only two to three after injection). hour). Although Thevetin has these advantages, using it as a cardiotonic drug still fails to attract universal attention. At present, in the absence of cardiotoxic drugs in our country, we look for importers of poisonous hairs.