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目的 :了解急性白血病多药耐药基因表达情况与临床化疗的关系。方法 :对 2 5例初治急性白血病病人采用逆转录 PCR技术检测多药耐药基因 (MDR1)。并对其阳性和阴性表达的 2组病人化疗效果进行分析。结果 :本组病例 MDR1阳性表达 6例 (2 4 %) ,以急性非淋巴细胞白血病为主 ,占 5例 ,这 6例 MDR1阳性的急性白血病患者 ,没有 1例经 1个疗程化疗即能完全缓解 ;MDR1阳性的急性白血病患者 ,完全缓解率为 2 / 6,MDR1阴性者完全缓解率为 84 %,P<0 .0 5。结论 :急性白血病患者MDR1阳性 ,则化疗效果较差 ,预后不良
Objective: To understand the relationship between the expression of multidrug resistance gene in acute leukemia and clinical chemotherapy. Methods : Multidrug resistance gene (MDR1) was detected by reverse transcription PCR in 25 patients with newly diagnosed acute leukemia. The chemotherapeutic effects of two groups of patients with positive and negative expression were analyzed. Results: 6 cases (24%) of MDR1 expression were positive in this group of cases, mainly in acute non-lymphocytic leukemia, accounting for 5 cases. None of these 6 cases of MDR1 positive acute leukemia patients could be completely treated with 1 course of chemotherapy. Remission; MDR1-positive acute leukemia patients, complete remission rate of 2 / 6, MDR1-negative complete remission rate was 84%, P lt; 0.05. Conclusion : MDR1 positive patients with acute leukemia have poor chemotherapy effect and poor prognosis