氨基双吡啶酮(Amrinone)是一非洋地黄类强心药,化学名为5-氨基-[3,4’-双吡啶]-6(1 H)-酮。经动物试验表明,该药具有特殊的正性肌特征,增加心脏收缩力的效应比洋地黄糖甙强,具有直接的正性收缩和扩张血管的双重作用。临床用于对洋地黄,利尿剂及血管扩张剂均无效的难治性心力衰竭,疗效显著。长期服用而引起的不良反应,国外尚在进一步考察。氨基双吡啶酮的合成大致有如下三条路线,均以4-甲基吡啶为起始原料。其中C法收率 Amrinone is a non-digitalis concenter chemical known as 5-amino- [3,4’-bipyridine] -6 (1H) -one. The animal experiments show that the drug has a special positive muscle characteristics, increased cardiac contractility stronger than digitalis glycosides, with direct positive contraction and dilate the dual role of blood vessels. Clinical for digitalis, diuretics and vasodilators are invalid refractory heart failure, a significant effect. Adverse reactions caused by long-term use, foreign countries are still under further investigation. Aminobispyridone synthesis generally have the following three routes, all with 4-methylpyridine as the starting material. Which C method yield