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目的：研究呼吸衰竭患者早期的肾功能损害及监测方法。方法：对21例呼衰合并心衰（观察Ⅰ组）、25例单纯呼衰（观察Ⅱ组）、43例对照组进行了血尿素氮、肌酐、β2－微球蛋白以及尿β2－微球蛋白、视黄醇结合蛋白、白蛋白、免疫球蛋白G、N－乙酰－β－氨基葡萄糖苷酶测定。结果：发现观察Ⅰ组、观察Ⅱ组尿系列微量蛋白均显著升高（P＜0．05～P＜0．01），尤其是观察Ⅰ组尿系列微量蛋白升高尤为明显，而血尿素氛、肌酐、β2－微球蛋白变化不明显。结论：提示呼衰患者往往伴有早期的肾功能损害，血液生化指标对其不敏感，而尿系列微量蛋白的测定对监测呼衰患者的肾功能进而指导临床治疗具有一定的意义。
Objective: To study the early renal damage and monitoring methods in patients with respiratory failure. Methods: Blood urea nitrogen, creatinine, β2-microglobulin and urinary β2-microglobulin were measured in 21 cases of respiratory failure complicated with heart failure (observation group Ⅰ), 25 cases of simple respiratory failure (observation group Ⅱ) and 43 cases of control group Protein, retinol binding protein, albumin, immunoglobulin G, N-acetyl-β-glucosaminidase assay. Results: It was found that in the observation group Ⅰ and the observation group Ⅱ, the urinary trace proteins were significantly increased (P <0.05 ~ P <0.01), especially in the observation group Ⅰ, especially in the urine microalbuminuria , Creatinine, β2-microglobulin did not change significantly. Conclusion: It is suggested that patients with respiratory failure often have early renal dysfunction, and biochemical indicators of blood are not sensitive to them. However, the determination of urinary trace proteins may be of significance in monitoring the renal function of patients with respiratory failure and guiding the clinical treatment.