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本实验用8只杂种犬复制了失血性休克的病理模型,按体重随机分为失血性休克(SH)组和失血性休克——地塞米松(SH—C)组。在实验过程中,通过调整血容量使动脉血压维持于5.3～6.7kPa,定期取动脉血测pH、PCO_2、HCO_3-BE和测血清中过氧化脂质的含量。结果表明:SH—D组的存活时间显著地长于SH组,动脉血pH、PCO_2,HCO~-_3和BE检测的结果是,随着失去性休克的进展,SH组和SH—D组均发生了强度相似的代谢性酸中毒;血清过氧化脂质的含量,随失血时间的延长,SH组逐渐增高,而SH—D组则逐渐降低,至失血后4.5小时,两组比较差异显著(P<0.05)。
In this experiment, 8 mongrel dogs were used to replicate the pathological model of hemorrhagic shock and were randomly divided into hemorrhagic shock (SH) group and hemorrhagic shock-SHX group. During the experiment, arterial blood pressure was maintained at 5.3 to 6.7 kPa by adjusting blood volume, and arterial blood was periodically taken to measure pH, PCO 2 , HCO 3 -BE and the content of lipid peroxide in serum. The results showed that the survival time of the SH-D group was significantly longer than that of the SH group. The results of the arterial blood pH, PCO_2, HCO~-_3, and BE were detected in both the SH group and the SH-D group as the stun shock progressed. The similar intensity of metabolic acidosis; serum lipid peroxide content, with the prolongation of blood loss, the SH group gradually increased, while the SH-D group gradually decreased to 4.5 hours after the blood loss, the two groups were significantly different (P <0.05).