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近年来,我们基于1,1’-联萘基-2,2’-二酚(BINOL)为手性源成功地发展了一类多手性中心化合物联萘-2-芳甲羟基-2’-醇(Ar-BINMOLs),它是BINOL的单苄醚化合物经过不对称[1,2]-Wittig重排合成得到的,涉及C—O键的断裂与新C—C的构建反应,由轴手性诱导产生新的碳手性中心,结构独特新颖,同时具有C2轴手性和sp3碳手性的光学纯醇酚类化合物.目前,Ar-BINMOLs作为新型手性配体应用于不对称催化反应已有不少的报道.基于BINOL衍生物以及近几年Ar-BINMOLs及其衍生物的研究进展,重点阐述了其作为新型手性配体或手性骨架在不对称催化反应中的应用研究进展.
In recent years, we have successfully developed a class of chiral center compounds, binaphthyl-2-hydroxymethyl-2’-dipyridyl, based on 1,1’-binaphthyl-2,2’-diphenol (BINOL) - alcohols (Ar-BINMOLs) synthesized by asymmetric [1,2] -Wittig rearrangement of the BINOL monobenzyl ether compound involving the cleavage of the C-O bond and the construction reaction of the new C-C, Chiral induction produces a new carbon chiral center, a unique new structure, with both C2-axis chiral and sp3 carbon chiral optical pure alcohol phenolic compounds.At present, Ar-BINMOLs as a new type of chiral ligand used in asymmetric catalysis Reaction has been reported quite a lot.Based on the research progress of BINOL derivatives and Ar-BINMOLs and their derivatives in recent years, the application of them as novel chiral ligands or chiral skeletons in asymmetric catalysis progress.