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[目的]探讨组蛋白甲基化转移酶(enhancer of zeste homolog2,EZH2)在卵巢肿瘤组织中的表达。[方法]应用免疫组织化学方法检测在正常卵巢组织和卵巢良、恶性肿瘤组织中EZH2蛋白表达水平。[结果]EZH2在正常卵巢组织和良性卵巢肿瘤组织、卵巢癌组织中的表达,差异有统计学意义(P﹤0.05)。在卵巢癌组织中,EZH2的表达在不同手术病理分期间比较,差异有统计学意义(P﹤0.05)。[结论]EZH2卵巢癌组织中高表达,与手术病理分期有关。
[Objective] To investigate the expression of enhancer of zeste homolog2 (EZH2) in ovarian tumor. [Method] Immunohistochemistry was used to detect the expression of EZH2 protein in normal ovarian tissue and ovarian benign and malignant tumor tissues. [Results] The expression of EZH2 in normal ovarian tissue, benign ovarian tumor and ovarian cancer was significantly different (P <0.05). In ovarian cancer, the expression of EZH2 was significantly different between different surgical pathological stages (P <0.05). [Conclusion] The high expression of EZH2 in ovarian cancer tissues is related to the pathological stage of surgery.