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目的 :观察国产西地那非对大鼠阴茎海绵体腔内压和阴茎勃起的作用并与进口西地那非比较。方法 :使用大鼠电刺激勃起模型 ,测定口服国产西地那非 (50mg·kg- 1)或进口西地那非 (50mg·kg- 1)对大鼠海绵体腔内压和阴茎勃起的影响。结果 :与用药前比较 ,服用国产西地那非可显著增高大鼠海绵体腔内压的幅度和张力 (P <0 .0 1) ,也能显著缩短勃起潜伏期和增加持续时间 (P <0 .0 1)。同样 ,等剂量进口西地那非也有相似作用 ,2组统计检验无显著差别。结论 :国产西地那非与进口西地那非均可显著增强电刺激引起的大鼠海绵体腔内压升高效应 ,也都显著增强阴茎勃起 ,两者药效相似
Objective: To observe the effect of domestic sildenafil on intracapsular pressure and penile erection in rats and compare with imported sildenafil. Methods: Eighteen rat models of erection were used to determine the effects of oral sildenafil (50 mg · kg -1) or imported sildenafil (50 mg · kg -1) on intracavernous pressure and penile erection in rats. Results: Compared with those before treatment, domestic sildenafil significantly increased the amplitude and tension of intracavernous pressure (P <0.01), and significantly shortened the erection latency and duration (P <0. 0 1). Similarly, the same dose of sildenafil imports have similar effects, no significant difference between the two statistical tests. CONCLUSION: Both domestic sildenafil and imported sildenafil can significantly enhance the intracavitary pressure rise effect induced by electrical stimulation in rats, and also significantly enhance penile erection, both of which have similar efficacy