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目的研究重组人生长激素(rhGH)对结直肠癌患者术后代谢、营养状态和术后切口愈合的影响。方法前瞻性地将82例结直肠癌患者随机分为治疗组(43例)和对照组(39例),治疗组手术后第1d开始皮下注射rhGH,对照组给予安慰剂,共用7d,分别在术前及术后3、7、14d检测血浆白蛋白(ALB)、前白蛋白(PA)及转铁蛋白(TF)水平。记录切口愈合情况。结果治疗组术后7d和术后14d的ALB、PA及TF水平均高于对照组(P<0.05),而对照组术后7d和术后14d的ALB、PA及TF水平高于术前和术后第3d(P<0.05)。治疗组术后切口愈合不良14例,对照组术后切口愈合不良24例;治疗组的切口愈合不良明显低于对照组(P<0.05)。结论结直肠癌根治术后的患者早期予以皮下注射rhGH可促进合成代谢、改善营养状态以及减少切口愈合不良的发生。
Objective To study the effects of recombinant human growth hormone (rhGH) on postoperative metabolism, nutritional status and postoperative incision healing in patients with colorectal cancer. Methods A total of 82 patients with colorectal cancer were prospectively divided into treatment group (43 cases) and control group (39 cases). In the treatment group, rhGH was injected subcutaneously on the first day after operation and placebo for 7 days in the control group The levels of albumin (ALB), prealbumin (PA) and transferrin (TF) were measured preoperatively and 3, 7 and 14 days after operation. Record incision healing. Results The levels of ALB, PA and TF in the treatment group at 7th day and 14th day after operation were significantly higher than those in the control group (P <0.05), while the levels of ALB, PA and TF in the control group at 7th day and 14th day after operation were significantly higher than those in the control group 3d after surgery (P <0.05). In the treatment group, 14 cases were cured by incision incision and 24 cases were cured by incision incision in the control group. The incision healing in the treatment group was significantly lower than that in the control group (P <0.05). CONCLUSIONS: RhGH injected subcutaneously in patients after radical resection of colorectal cancer can promote the synthesis and metabolism, improve the nutritional status and reduce the incision healing.