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目的：探讨舍曲林与氯米帕明治疗强迫症的临床疗效和安全性。方法将62例强迫症患者随机分为两组，分别给予舍曲林、氯米帕明治疗，观察8周。采用耶鲁‐布朗强迫量表、副反应量表评定临床疗效及不良反应。结果治疗2周末起两组耶鲁‐布朗强迫量表评分均较治疗前显著降低（P＜0．01），同期两组比较差异无显著性（P＞0．05）。两组总有效率比较差异无显著性（P＞0．05），舍曲林组不良反应发生率显著低于氯米帕明组（P＜0．01）。结论舍曲林治疗强迫症疗效显著，与氯米帕明相当，但舍曲林安全性高。“,”Objective To explore the efficacy and safety of sertraline and clomi‐pramine in the treatment of obsessive‐compulsive disorder (OCD) .Methods Six‐ty‐two OCD patients were randomly divided into two groups treated with sertraline or clomipramine for 8 weeks .Efficacies were assessed with the Yale‐Brown Obsessive Compulsive Scale (Y‐BOCS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 2nd week the Y‐BOCS scores of both groups lowered more significantly compared with pretreatment (P0 .05) .There was no sig‐nificant group difference in total effective rate (P> 0 .05) ,the incidence of adverse reaction was signifi‐cantly lower in sertraline than clomipramine group (P<0 .01) .Conclusion Sertraline equivalent to clomi‐pramine has an evident effect in OCD ,but the former does higher safety .