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目的幽门螺杆菌（Ｈｐ）与胃酸的关系尚不明确．了解胃粘膜中组胺的含量对于揭示Ｈｐ与胃酸关系的本质进而阐述Ｈｐ的发病机制有重要意义．方法共５８例，男４７例，女１１例，年龄１８岁～６３岁．诊断十二指肠溃疡（ＤＵ）２３例，红斑渗出性胃炎３５例．每例患者在作出内镜诊断后取胃窦幽门前和胃体上部大弯侧粘膜各４块，其中胃体的３块组织直接放入０５ｍｌ塑料离心管后立即投入液氮中保存待测，其他５块分别作快速尿素酶试验（ＣＬＯｔｅｓｔ）、Ｈｐ培养、组织Ｗａｒｔｈｉｎ－Ｓｔａｒｙ银染色和ＨＥ染色．组胺测定采用放射免疫方法，药盒购自Ｉｍｍｕｎｏｔｅｃｈ公司（法国），具体操作按说明进行．结果２３例ＤＵ中Ｈｐ阳性率７３９％；３５例胃炎中Ｈｐ阳性率５２２％．组织病理学诊断轻度炎症３０例（活动性炎４例）；中度炎症２２例（活动性炎１５例）；重度炎症３例，均为活动性炎．Ｈｐ阳性者多为活动性炎症，但有少数Ｈｐ阳性而未见明显活动性炎表现．组胺含量在Ｈｐ阳性ＤＵ与阴性者无显著差异（１９１４μｇ／ｇ±１１７６μｇ／ｇｖｓ２３６８μｇ／ｇ±１２４９μｇ／ｇ，Ｐ＞００５），但活动期ＤＵ者（ｎ＝１２）组胺含量显著低于愈合期（ｎ＝１１）（１５２?
Purpose The relationship between Helicobacter pylori (Hp) and gastric acid is unclear. To understand the histamine content of gastric mucosa in order to reveal the nature of the relationship between Hp and gastric acid and then explain the pathogenesis of Hp is of great significance. Methods A total of 58 cases, 47 males and 11 females, aged 18 years to 63 years. Diagnosis of duodenal ulcer (DU) in 23 cases, 35 cases of erythema exudative gastritis. Each patient after taking the endoscopic diagnosis of gastric pyloric anterior and gastric curvature of the greater curvature of the mucosa of the four, in which the body of the three tissues directly into the 0 5ml plastic centrifuge tube immediately after the liquid nitrogen to be preserved Test, the other five were rapid urease test (CLOtest), Hp culture, tissue Warthin-Stary silver staining and HE staining. Histamine assay using radioimmunoassay kit from Immunotech (France), the specific operation according to the instructions. Results The positive rate of Hp in 23 cases was 739%. The positive rate of Hp in 35 cases of gastritis was 522%. Histopathological diagnosis of mild inflammation in 30 cases (active inflammation in 4 cases); moderate inflammation in 22 cases (15 cases of active inflammation); severe inflammation in 3 cases, are active inflammation. Hp-positive were mostly active inflammation, but a small number of Hp positive and no significant active inflammation. Histamine content in Hp-positive DU and negative no significant difference (19.14μg / g ± 1176μg / gvs2368μg / g ± 12.49μg / g, P> 005), but active DU (n = 12) histamine content was significantly lower than the healing period (n = 11) (15 2?