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在清醒麻痹大鼠观察了电刺激和损毁脑桥蓝斑核对缝隙大核神经元自发放电及其对伤害性刺激反应的影响。大多数神经元放电频率在刺激蓝斑核后减少;损毁后增加。大多数对伤害性刺激的反应可被蓝斑核刺激所压抑;损毁后则加强。损毁蓝斑核的效应在损毁后10分钟时最显著,以后随时间而减弱。本工作说明蓝斑核对缝隙大核神经元活动有紧张性抑制作用,这种抑制作用可能与蓝斑核在脑干水平拮抗镇痛有关。
The effects of electrical stimulation and lesion of pontine nucleus pulposus on the spontaneous discharges of noxious nucleus neurons and their noxious stimulation responses were observed in consciously paralyzed rats. The discharge frequency of most neurons decreased after stimulation of locus coeruleus; increased after injury. Most responses to noxious stimuli can be suppressed by locus coeruleus stimulation; The effect of rupture of the locus coeruleus is most pronounced 10 minutes after the rupture and later decreases with time. This work shows that locus coeruleus can check the activity of neurons in the nucleus of kyphosis, which may be related to the antagonism of locus coeruleus at the brainstem of locus coeruleus.