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本文用动物试验,进一步确定化疗与免疫的相互协同作用。实验用曼氏血吸虫为波多黎各株,动物为CBB/Ca近交系雌性小鼠及Punkin Hartley半近交雌性豚鼠。用500条经20krad的~(60)Coγ射线照射的尾蚴经皮肤接种动物,4wk后用150条正常尾蚴攻击感染动物,并用正常动物作对照。在感染后6d,每只动物肌注吡喹酮(PZQ)500mg。在体内进行了3种实验。1.中性白细胞的耗竭:上述对照、PZQ治疗对照、免疫接种
In this paper, animal experiments to further confirm the synergistic effect of chemotherapy and immune. The S. mansoni used in the experiment were Puerto Rico strains, animals were CBB / Ca inbred female mice and Punkin Hartley semi-adult female guinea pigs. Animals were inoculated with 500 cercariae irradiated with 20 krad of ~ (60) Co gamma rays, and infected animals were challenged with 150 normal cercariae after 4 weeks and compared with normal animals. Six days after infection, praziquantel (PZQ) 500 mg was intramuscularly injected into each animal. Three experiments were performed in vivo. Neutrophil depletion: The above control, PZQ treatment control, immunization