如何改进疫苗的效果?其答案可能不在于所用疫苗抗原的免疫原性或所使用的佐剂,而在于疫苗注射机体的部位。据美国疾病控制中心(CDC)的一项报告说,有证据表明,Merck药厂生产的血源性乙型肝炎疫苗的效果取决于注射部位,1981年该疫苗被批准前的研究表明,90%以上的疫苗接受者能产生保护性抗体。但是,还有报告说 How to improve the effectiveness of the vaccine? The answer may not lie in the immunogenicity of the vaccine antigen used or the adjuvant used, but in the area where the vaccine is injected into the body. According to a report by the Centers for Disease Control and Prevention (CDC), there is evidence that the effect of a Hepatitis B vaccine produced by Merck Pharmaceuticals depends on the site of injection, and that prior to the approval of the vaccine in 1981, 90% The vaccine recipients above can produce protective antibodies. However, there are reports