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随着近代免疫学、生理学、药物化学的长足进展和对麻风杆菌动物实验的深入研究,关于抗麻风病的化学药物治疗问题、正在经历着一场变革,过去的一些意见正在发生改变。譬如DDS:自1908年From wittman合成,1941年Fagtt用其衍生普洛明(promin)治疗麻风获效以来,临床应用已近四十年,对它最合适的有效剂量一直有很大争论,有的主张用大剂量,有的则极力主张用小剂量;在服法上,一般主张从小剂量开始,逐步递增至维持量;目前不主张这样服药,为了防止砜类药的耐药性,也正在深入研究,并且有日趋成熟的方案,等等,这些都需要我们加以认真地学习和研究。另外,鉴于几乎所有抗麻风化学药物都是从抗结核病化学治疗的药物引伸而来,因此,对
With the recent advances in immunology, physiology, and medicinal chemistry in modern times and in-depth study of experiments on leprosy animals, there has been a change in the treatment of chemotherapeutics against leprosy. Some of the past opinions are undergoing changes. For example, DDS: Since Wittman’s synthesis in 1908 and its use in 1941 for the treatment of leprosy with its derivative promin have been in clinical use for almost 40 years, there has been considerable controversy over the most appropriate effective dose for Advocated the use of large doses, while others strongly advocated the use of small doses; in the service method, the general idea of starting from a small dose, and gradually increased to maintain the amount; currently does not advocate such medication, in order to prevent sulfone drug resistance, is also In-depth study, and there are more and more mature programs, and so on, which require us to seriously study and research. In addition, given that almost all anti-leprosy drugs are derived from anti-tuberculosis drugs,