醛固酮合成酶基因-344T/C多态性与山东省汉族人原发性高血压相关性

来源 :中华医学遗传学杂志 | 被引量 : 0次 | 上传用户：sym409198933

【摘要】

：

目的研究醛固酮合成酶基因-344T/C多态性是否与山东省汉族人原发性高血压相关.方法放免法检测山东省147例原发性高血压患者血浆肾素活性(plasma renin activity, PRA)和醛固

【作者】

：

孙晓健侯晓菲刘少荣刘文波陶志刚李建远

【机构】

：

264000,264000,264000

【出处】

：

中华医学遗传学杂志

【发表日期】

：

2004年5期

【关键词】

：

醛固酮合成酶基因多态性原发性高血压低肾素

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目的研究醛固酮合成酶基因-344T/C多态性是否与山东省汉族人原发性高血压相关.方法放免法检测山东省147例原发性高血压患者血浆肾素活性(plasma renin activity, PRA)和醛固酮浓度(plasma aldosterone concentration, PAC),以PAC/PRA比值将高血压患者分为低肾素、正常肾素或高肾素组;聚合酶链反应-限制性片段长度多态性技术检测高血压(147例)和对照组(110名)醛固酮合成酶基因-344T/C多态性,χ2检验比较各组基因型和等位基因频率.结果对

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醛固酮合成酶基因-344T/C多态性与山东省汉族人原发性高血压相关性

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