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目的:探讨纳洛酮在中重度新生儿缺氧缺血性脑病(HIE)治疗中的临床效果。方法:收集2009年2月～2011年2月HIE患儿90例,按随机数字表法分为观察组和对照组,每组45例。对照组给予三项支持疗法、三项对症处理、应用脑细胞活化剂及抗感染等综合疗法,观察组在此基础上加用纳洛酮。比较两组疗效、NBNA评分和不良反应。结果:观察组总有效率为95.56%(43/45),对照组有效率为77.78%(35/45),观察组总有效率显著高于对照组(P<0.05)。两组用药后第3天、第5天时NBNA评分均较用药前显著升高(P<0.05),且观察组用药后第3天、第5天时NBNA评分均显著高于对照组(P<0.05)。两组均未发生明显不良反应。结论:在中重度HIE治疗中应用纳洛酮能显著提高疗效,无明显不良反应,值得临床推广应用。
Objective: To investigate the clinical effect of naloxone in the treatment of moderate and severe neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Totally 90 children with HIE from February 2009 to February 2011 were divided into observation group and control group according to random number table method, with 45 cases in each group. Control group was given three supportive therapies, three symptomatic treatment, the application of brain cell activators and anti-infective and other comprehensive treatment, the observation group on the basis of the use of naloxone. The curative effect, NBNA score and adverse reaction were compared between the two groups. Results: The total effective rate was 95.56% (43/45) in the observation group and 77.78% (35/45) in the control group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The NBNA score was significantly higher (P <0.05) at 3 and 5 days after treatment in both groups, and NBNA scores were significantly higher in the observation group than those in the control group on the 3rd and 5th days ). No significant adverse reactions occurred in both groups. Conclusion: The application of naloxone in the treatment of moderate and severe HIE can significantly improve the curative effect without obvious adverse reactions, which is worthy of clinical application.