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一般认为,慢性缺氧动物肺血管反应性增高与收缩增强是产生肺动脉高压的重要基础。本文的目的是探讨在肺动脉压随缺氧时间延长而递增的过程中,肺血管反应性是否也平行地增高。实验用雄性Wistar大鼠,体重200～270克,随机分为平原对照组、模拟5000米高度低压舱内连续缺氧4天、10天、20天、30天等五个组,每组8只动物。在12％乌拉坦溶液(10ml/kgBW)腹腔麻醉下行右心导管术测肺动脉压(PAP)与右室内压最大上升速率(dp/dt max)后,处死动物,取主肺动脉制备血管条(10×1mm),垂直悬挂于管状恒
It is generally believed that pulmonary hypoxia in rats with increased pulmonary vascular reactivity and enhanced contractility is an important basis for pulmonary hypertension. The purpose of this article is to investigate whether pulmonary vascular reactivity is also increased in parallel as the pulmonary arterial pressure increases with hypoxia duration. Experimental male Wistar rats, weighing 200-270 g, were randomly divided into five groups: control group, placenta, hypoxia, hypoxia, hypoxia, animal. The right pulmonary artery catheter (PAP) and the maximum rate of right ventricular pressure (dp / dt max) were performed in 12% urethane solution (10 ml / kg BW) under anesthesia. Animals were sacrificed and the main pulmonary artery × 1mm), hanging vertically in the tubular constant