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目的 :研究雌激素受体 ( ER) α与 β在原发性肝细胞癌中的表达水平及分布规律。方法 :用免疫组织化学方法检测了 63例原发性肝细胞癌及 63例非肝癌肝组织的 ERα与 ERβ的表达。结果 :原发性肝细胞癌中 ERα与 ERβ的阳性率分别为 2 7% ( Edmondson分级 级的肝癌为 2 3%、 级为 2 8%、 级为 2 9% )和 1 3% ( Edmondson分级 级的肝癌为31 %、 级为 8%、 级为 7% ) ,非肝癌肝组织中 ERα与 ERβ的阳性率分别为 32 % (肝硬化 :30 %、肝海绵状血管瘤 :32 %、正常肝组织 :5 0 % )和 2 9% (肝硬化 :30 %、肝海绵状血管瘤 :2 6%、正常肝组织 :2 5 % )。肝癌与非癌肝组织比较 ERα阳性率无显著差异 ( P>0 .0 5 ) ,但ERβ阳性率有显著意义 ( P<0 .0 5 ) ;Edmondson分级 级的肝癌 ERβ的阳性率与 、 级肝癌比较 ,统计学差异有显著性 ( P<0 .0 5 ) ;肝癌组内 ERα阳性较 ERβ有显著差异 ( P<0 .0 5 )。结论 :原发性肝细胞癌可能具有一定的激素依赖性 ,肝癌的发生、发展及预后可能与ERα的表达无关 ,但与肝癌组织中 ERβ含量的降低有关
Objective: To study the expression and distribution of estrogen receptor (α) and β in primary hepatocellular carcinoma (HCC). Methods: The expressions of ERα and ERβ in 63 cases of primary hepatocellular carcinoma and 63 cases of non-hepatocellular carcinoma were detected by immunohistochemistry. Results: The positive rates of ERα and ERβ in primary hepatocellular carcinoma were 27% (Edmondson grade 23%, grade 28%, grade 29%) and 13% (Edmondson grade Grade liver cancer was 31%, grade 8% and grade 7%). The positive rates of ERα and ERβ in non-HCC liver tissues were 32% (cirrhosis: 30%, hepatic cavernous hemangioma: 32%, normal Liver tissue: 50%) and 29% (liver cirrhosis: 30%, hepatic cavernous hemangioma: 26%, normal liver tissue: 25%). The positive rate of ERα was not significantly different between hepatocellular carcinoma and non-cancerous liver tissues (P> 0.05), but the positive rate of ERβ was significant (P0.05). The positive rate of ERβ in Edmondson grade liver cancer was There was significant difference between the two groups (P <0.05). The positive expression of ERα in liver cancer group was significantly different from that of ERβ (P <0.05). Conclusion: Primary hepatocellular carcinoma may be hormone-dependent. The occurrence, development and prognosis of hepatocellular carcinoma may not be related to the expression of ERα, but may be related to the decrease of ERβ in hepatocellular carcinoma