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目的探讨年龄≥50岁结节病患者的临床特征。方法回顾性分析60例年龄≥50岁结节病患者(观察组)主要临床表现、误诊、肺外累及、辅助检查及治疗情况,并与同期确诊的72例年龄<50岁结节病患者(对照组)进行比较。结果与对照组比较,观察组女性患者比例明显增多(P<0.01);误诊率、肺外累及、体质量减轻及阻塞性通气功能障碍发生率均较对照组增高(P<0.05);发热及自行缓解率减低(P<0.05);2组呼吸道症状、临床分期及激素治疗有效率比较差异无统计学意义(P>0.05)。结论≥50岁结节病患者与年龄<50岁结节病患者部分临床特征不同。
Objective To investigate the clinical features of patients with sarcoidosis aged ≥50 years. Methods The clinical manifestations, misdiagnosis, extrapulmonary involvement, auxiliary examination and treatment of 60 cases of sarcoidosis patients aged 50 years and older (observation group) were retrospectively analyzed and compared with 72 cases of patients with sarcoidosis Control group) for comparison. Results Compared with the control group, the proportion of women in the observation group was significantly increased (P <0.01). The rates of misdiagnosis, extrapulmonary involvement, weight loss and obstructive ventilatory dysfunction were significantly higher in the observation group than those in the control group (P <0.05) (P <0.05). There was no significant difference in respiratory symptoms, clinical stage and hormone therapy between the two groups (P> 0.05). Conclusion Some clinical features of patients with sarcoidosis at age 50 and those with sarcoidosis at age <50 years are different.