细胞因子和相应受体结合 ,引发细胞内信号分子级联反应 ,而SOCS蛋白负性调节细胞因子的JAK STATs信号传导途径 ,且SOCS蛋白作用的直接靶点不同。另一方面STATs可以和SOCS基因的调控序列结合 ,调节SOCS基因的表达。小鼠SOCS基因敲除实验显示 ,该信号负反馈途径有助于调节细胞适度应答。结构上 ,SOCS中间为SH2结构域 ,C 末端是保守的SOCS盒 ,因N 末端差异较大而将SOCS家族分为 5组 Cytokines bind to the corresponding receptors, triggering a cascade of intracellular signal molecules, whereas SOCS negatively regulates the JAK STATs signaling pathway of cytokines, and the direct targets of SOCS proteins are different. On the other hand, STATs can bind to the regulatory sequences of SOCS gene and regulate the expression of SOCS gene. Mouse SOCS knockout experiments show that the signal negative feedback pathway helps regulate the moderate response of cells. Structurally, the middle SOCS is the SH2 domain and the C-terminus is a conserved SOCS cassette. The SOCS families are divided into five groups due to the large N-terminal difference