论文部分内容阅读
妊娠期高血压疾病是妊娠期特有的疾病,发病率高,对妊娠妇女、胎儿及新生儿危害极大,是导致孕产妇和围生儿死亡率增加的主要原因。近半个世纪,国内外学者对其发病机制进行了大量研究,有过度炎症反应、血管内皮损伤、氧化应激、母胎免疫平衡失调、滋养细胞缺血及遗传基因易感性等学说,但至今病因尚未阐明。众多研究发现,妊娠期高血压疾病具有较高遗传倾向,与某些基因多态性有关,与多基因有关,且更易发生原发性高血压。相关基因的突变可导致基因表达异常,使基因产物出现数量及功能异常,而诱发妊娠期高血压疾病。
Hypertensive disorder of pregnancy is a unique disease during pregnancy, the high incidence of pregnancy-threatening women, fetuses and newborns, is the leading cause of increased maternal and perinatal mortality. Nearly half a century, scholars at home and abroad have carried out a large number of studies on the pathogenesis of excessive inflammatory response, vascular endothelial injury, oxidative stress, maternal immune imbalance, trophoblastic ischemia and genetic susceptibility theory, but so far the cause Not yet clarified. Numerous studies have found that gestational hypertension has a high genetic predisposition, is associated with some genetic polymorphisms, is associated with multiple genes, and is more prone to essential hypertension. Mutation of related genes can lead to abnormal gene expression, so that the number of gene products and dysfunction, and induced hypertensive disorders during pregnancy.