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目的探讨甲型肝炎高流行区疫苗免疫方案。方法观察新生儿母传抗ＨＡＶ抗体的衰减及处于甲型肝炎流行不同阶段儿童甲型肝炎病毒感染率随年龄上升的规律。结果新生儿母传抗体的阳性率按ｌｏｇｉｓｔｉｃ曲线下降，１３个月内从９７．４％下降为５．０％；非流行期儿童甲型肝炎病毒感染率从１．５岁起随年龄上升，２岁前保持在１０％以内；流行期儿童甲型肝炎病毒感染率随年龄增加而起点提前，速度加快。鉴于甲型肝炎发病随年龄上升的起点滞后于感染，认为甲型肝炎高流行区新生儿甲型肝炎母传抗体向自然感染抗体转换的“窗口期”是在出生后１２～２４个月。结论根据流行情况与经济条件，儿童适宜的甲型肝炎疫苗免疫时机一般选择在１２～２４月龄
Objective To explore the vaccine immunization program in high-endemic area of hepatitis A Methods To observe the decay of anti-HAV antibody in neonates and the regularity of hepatitis A virus infection with age in different stages of hepatitis A epidemic. Results The positive rate of mother-to-body antibody in neonates decreased according to the logistic curve and decreased from 97.4% to 5.0% within 13 months. The prevalence of hepatitis A virus in non-epidemic children increased with age from 1.5 years old, 2 years ago remained at 10%; prevalence of hepatitis A virus infection rate with age and start earlier, faster. In view of the fact that the onset of hepatitis A lagged from infection with the onset of age, the “window period” of conversion of neonatal hepatitis B to maternal antibodies to naturally-infected antibodies in the high endemic area of hepatitis A is considered to be 12 to 24 months after birth. Conclusion According to the prevalence and economic conditions, the appropriate timing of hepatitis A vaccine in children is generally 12 to 24 months of age