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目的分析研究四联疗法治疗幽门螺杆菌阳性消化性溃疡的临床疗效及安全性。方法将64例幽门螺杆菌阳性消化性溃疡患者随机分两组各32例,观察组采用四联疗法,对照组采用三联疗法。结果观察组有效率为93.75%,对照组有效率为81.25%,两组比较差异有统计学意义(P<0.05);观察组Hp根除率为96.88%,对照组为组81.25%(P<0.05);两组均未见明显不良反应发生。结论四联疗法治疗幽门螺杆菌阳性消化性溃疡,Hp根除率高,患者顺应性好,且不良反应少,可在临床上推广应用。
Objective To analyze the clinical efficacy and safety of quadruple therapy in the treatment of Helicobacter pylori positive peptic ulcer. Methods 64 cases of H. pylori-positive peptic ulcer patients were randomly divided into two groups of 32 cases, the observation group with quadruple therapy, the control group with triple therapy. Results The effective rate was 93.75% in the observation group and 81.25% in the control group, with significant difference between the two groups (P <0.05). The eradication rate of Hp in the observation group was 96.88% and that in the control group was 81.25% (P <0.05) ); No obvious adverse reactions occurred in both groups. Conclusion The quadruple therapy for Helicobacter pylori positive peptic ulcer, Hp eradication rate, patients with good compliance, and less adverse reactions, which can be widely applied in clinic.