2006年1月~2011年3月在我院门诊治疗中遇见2例皮试阴性,肌肉注射后产生破伤风过敏,经治疗后症状缓解。现报告如下。病例1:女,26岁,手指被菜刀划伤,伤口包扎处理后,来我院进行破伤风预防治疗,询问病史无破伤风注射史,正规皮试液配制后给予皮试,20min后,结果阴性,给予肌注破伤风注射液6min后,患者随即出现头晕、恶心、胸闷、呼吸 January 2006 ~ March 2011 in our hospital outpatient treatment met two cases of skin test negative, tetanus after intramuscular injection of allergy, the symptoms relieved after treatment. The report is as follows. Case 1: Female, 26 years old, fingers were chopped with a kitchen knife, wound dressing treatment came to our hospital for tetanus prevention and treatment, history of non-tetanus injection history, formal skin test solution was given after the skin test, 20min, the results Negative, given intramuscular injection of tetanus after 6min, the patient immediately dizziness, nausea, chest tightness, breathing