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目的探讨连续性肾脏替代治疗(CRRT)对急性肾功能衰竭(ARF)患者血浆细胞因子的影响。方法对42例急性肾功能衰竭患者进行CRRT治疗,使用ELISA法检测治疗前和治疗后4、12、24、48 h血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6、IL-8的浓度,并与同期健康人群做比较。结果 ARF患者TNF-α、IL-1β、IL-6、IL-8血浆浓度均显著高于正常对照组(P<0.01),4种细胞因子在CRRT治疗4 h开始后显著下降,12 h时浓度降至最低,24～48 h有不同程度的回升,但仍低于治疗前水平。结论 CRRT能有效清除ARF患者血浆细胞因子,从而阻断炎症反应。
Objective To investigate the effect of continuous renal replacement therapy (CRRT) on plasma cytokines in patients with acute renal failure (ARF). Methods 42 patients with acute renal failure were treated with CRRT. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL- 1β), IL-6 and IL-8, and compared with healthy people at the same period. Results The plasma concentrations of TNF-α, IL-1β, IL-6 and IL-8 in ARF patients were significantly higher than those in normal controls (P <0.01). The levels of four cytokines decreased significantly after 4 hours of CRRT treatment. Concentration down to a minimum, 24 ~ 48 h have varying degrees of recovery, but still lower than the pre-treatment levels. Conclusion CRRT can effectively clear the plasma cytokines in patients with ARF, thus blocking the inflammatory response.