目的 :研究运脾复方儿宝颗粒对小儿厌食症大鼠模型下丘脑 β-内啡肽的影响。方法 :模拟小儿厌食症病因建立动物模型 ,用免疫组化方法观察动物下丘脑β-内啡肽的分布 ,结合图像分析技术测定相对含量。结果 :模型动物下丘脑 β-内啡肽含量降低(P<0.05) ,治疗组β-内啡肽含量增高(P<0.05)。结论 :运脾复方能促进模型动物下丘脑β-内啡肽合成 ,可能是治疗小儿厌食症的重要作用机理之一。 Objective: To study the effect of Yunpi Fufang Erbao Granules on β-endorphin in the hypothalamus of a rat model of anorexia nervosa. Methods: To simulate the etiology of infantile anorexia and establish an animal model. The distribution of β-endorphin in the hypothalamus was observed by immunohistochemistry and the relative content was determined by image analysis. RESULTS: β-endorphin content in hypothalamus of model animals was decreased (P<0.05), and β-endorphin content was increased in the treatment group (P<0.05). Conclusion: Yunpi Fufang can promote the synthesis of β-endorphin in the hypothalamus of model animals, which may be one of the important mechanisms in the treatment of anorexia in children.