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目的:观察自拟三黄粉联合奥曲肽治疗肝硬化并上消化道大出血的临床疗效。方法:将62例患者随机分为治疗组32例与对照组30例,治疗组采用自拟三黄粉联合奥曲肽治疗,对照组采用垂体后叶素治疗,观察疗效、止血起效时间、再出血率及不良反应。结果:临床疗效总有效率治疗组为93.75%,对照组为73.33%,2组比较,差异有显著性意义(P<0.05)。平均止血起效时间治疗组为(6.45±3.96)h,对照组为(15.62±6.98)h,治疗组平均止血起效时间较对照组明显缩短。再出血率治疗组为16.67%,对照组为59.10%,2组比较,差异有非常显著性意义(P<0.01)。结论:自拟三黄粉联合奥曲肽治疗肝硬化并上消化道大出血止血效果较垂体后叶素显著,是内科急诊治疗肝硬化并食管下段或胃底静脉曲张破裂大出血的有效药物。
Objective: To observe the curative effect of self-made three yellow powder combined with octreotide on cirrhosis and upper gastrointestinal hemorrhage. Methods: Sixty-two patients were randomly divided into treatment group (n = 32) and control group (n = 30). The treatment group was treated with self-made Sanhuang powder combined with octreotide and the control group was treated with pituitrin. The curative effect, hemostasis onset time, And adverse reactions. Results: The total effective rate was 93.75% in the treatment group and 73.33% in the control group. There was significant difference between the two groups (P <0.05). The mean time to onset of onset of bleeding was (6.45 ± 3.96) h in the control group and (15.62 ± 6.98) h in the control group, and the mean hemostasis onset time in the treatment group was significantly shorter than that in the control group. The rate of rebleeding was 16.67% in the treatment group and 59.10% in the control group. There was significant difference between the two groups (P <0.01). Conclusion: The self-made three yellow powder combined with octreotide in the treatment of cirrhosis and upper gastrointestinal bleeding is more effective than pituitrin in the treatment of cirrhosis and esophageal or gastric variceal bleeding effective drugs.