ZnS nano-particles with average sizes of 10 nm and 5 nm were fabricated by sol-gel method, and their pressure-induced phase transformations were in-situ examined in a diamond anvil cell by energy dispersive X-ray diffraction (EDXD) from ambient pressure to 35.0 GPa. From the obtained interplanar spacing data, the volume compression ratios were derived at different pressures, and then the bulk modulus and its pressure derivative were obtained by fitting to the Murnaghan equation. It is found that both ZnS nano-particles initially in the zinc-blende phase transformed to cubic NaCl structure in the presence of pressure and the transition was reversible when the pressure was released. Moreover, it is suggested that a smaller particle size will induce a larger transition pressure. ZnS nano-particles with average sizes of 10 nm and 5 nm were fabricated by sol-gel method, and their pressure-induced phase transformations were in-situ examined in a diamond anvil cell by energy dispersive X-ray diffraction (EDXD) from ambient pressure to 35.0 GPa. From the obtained interplanar spacing data, the volume compression ratios were derived at different pressures, and then the bulk modulus and its pressure derivative were obtained by fitting to the Murnaghan equation. It is found that both both ZnS nano- in the zinc-blende phase transformed to cubic NaCl structure in the presence of pressure and the transition was reversible when the pressure was released. Moreover, it is suggested that a smaller particle size will induce induce a larger transition pressure.