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用免疫组化方法检测了凋亡抑制基因蛋白Ｂｃｌ－２蛋白在基底细胞癌（ＢＣＣ）中的表达，同时分析比较了ｐ５３蛋白、Ｐａｎ－ｒａｓ蛋白和增殖细胞核抗原（ＰＣＮＡ）的表达。结果ＢＣＣ中２１／２１例Ｂｃｌ－２蛋白阳性，且几乎所有肿瘤细胞均呈阳性胞浆反应；５／１０例ｐ５３蛋白阳性，阳性细胞率小于５０％；Ｐａｎ－ｒａｓ蛋白在１０／１０例中均阴性；ＰＣＮＡ在９／１０例中阳性，但阳性细胞率小于１０％。这些表明，ＢＣＣ是一种低增殖活性肿瘤。而Ｂｃｌ－２蛋白的普遍过度表达提示凋亡抑制作用可能是ＢＣＣ发病及临床生物学行为的分子生物学机制之一。
The expression of Bcl-2 protein in basal cell carcinoma (BCC) was detected by immunohistochemistry. The expression of p53 protein, Pan-ras protein and proliferating cell nuclear antigen (PCNA) were also analyzed. Results Bcl-2 protein was positive in 21/21 cases of BCC, and almost all tumor cells showed positive cytoplasmic reaction; 5/10 cases were positive for p53 protein, and the positive cell rate was less than 50%; Pan-ras protein was 10/10 All were negative; PCNA was positive in 9/10 cases but the positive cell rate was less than 10%. These show that BCC is a tumor with low proliferative activity. The overexpression of Bcl-2 protein suggests that apoptosis inhibition may be one of the molecular biological mechanisms of BCC pathogenesis and clinical biological behavior.