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目的：探讨认知行为治疗对伴躯体症状抑郁症患者的疗效。方法将符合CCMD-3诊断标准且躯体不适症状≥3项的60例抑郁症患者随机分成艾司西酞普兰合并认知行为治疗组和单用艾司西酞普兰组，使用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）评定治疗前及治疗8周后精神症状。结果两组治疗后HAMD、HAMA评分均较治疗前显著降低（P＜0.05）。治疗8周末，两组间HAMD、HAMA评分差异有显著性（P＜0.05），合并认知行为治疗组HAMD总分、焦虑/躯体化因子分显著低于单用艾司西酞普兰组（P＜0.01）。结论认知行为治疗对伴躯体症状抑郁症患者有效，尤其对改善躯体症状效果优于单用药物治疗。“,”Objective To investigate the efficacy of cognitive-behavioral therapy(CBT) in depressions presented with somatic complaints. Methods 60 patients ,who met CCMD-3 criteria of major depression, presented with more than 3 somatic complaints were randomly divided into Escitalopram combined with CBT group and Escitalopram group. The efficacy were assessed with Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) before and after 8weeks treatment. Result The total scores of HAMD and HAMA significantly decreased after 8weeks treatment in both groups(P<0.05).The total scores of HAMD and the factor scores of anxiety/somatization in Escitalopram combined with CBT group were significantly lower than Escitalopram group(P<0.05). Conclusion CBT are more effective in treatment of depressions than Escitalopram, especial y in those with somatic complaints.