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目的研究肝癌肝切除后血浆血管内皮生长因子(VEGF)和转化生长因子-β1(TGF-β1)的变化,与生长抑素(SST)对肝切除后血浆VEGF和TGF-β1变化的影响。方法将2002~2003年拟行手术治疗的20例肝癌病人随机分为治疗组与对照组,每组各10例,用双抗体夹心ELISA方法检测病人手术前后血浆VEGF和TGF-β1的浓度变化。结果对照组术后血浆VEGF与TGF-β1浓度较术前明显增高(P<0·05)。SST治疗组术后血浆VEGF与TGF-β1浓度较对照组术后明显降低(P<0·05)。结论应用SST能明显降低血浆VEGF与TGF-β1的浓度,VEGF与TGF-β1促残瘤生长的作用可能受到抑制,提示SST对于预防肝癌手术后残瘤的复发可能有作用。
Objective To study the changes of plasma vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) after hepatectomy and the effect of somatostatin (SST) on the changes of plasma VEGF and TGF-β1 after hepatectomy. Methods Twenty patients with hepatocellular carcinoma who underwent surgical treatment from 2002 to 2003 were randomly divided into treatment group and control group, with 10 cases in each group. The changes of plasma VEGF and TGF-β1 levels before and after surgery were detected by double antibody sandwich ELISA. Results The plasma levels of VEGF and TGF-β1 in the control group were significantly higher than those before operation (P <0.05). The plasma levels of VEGF and TGF-β1 in the SST group were significantly lower than those in the control group after operation (P <0.05). Conclusion The application of SST can significantly decrease the concentration of VEGF and TGF-β1 in plasma, and the inhibition of the growth of VEGF and TGF-β1 may be inhibited, suggesting that SST may play an important role in the prevention of recurrence of liver cancer after operation.