Objective:The aim of this study was to evaluate the effects and safety of brucea javanica oil,mitomycin and BCG for preventing postoperative relapse of superficial bladder cancer through perfusion.Methods:From July 2000 to May 2006,178 patients with primary superficial bladder cancer(Ta-1,G1-2) were divided into three groups after operation in random:57 patients in group A received perfusion of 60 mL 10% brucea javanica oil,and 66 patients in group B received perfusion of 20 mg mitomycin while 55 patients in group C received perfusion of 120 mg BCG.Eighteen perfusions per patient were carried out regularly a week after operation.Patients were followed up for clinical,analytical and cystoscopic evaluations every 3 months for 2 years.The tumor relapse rates and side effects after treatment were evaluated.Results:The relapse rate was 14.04%(8/57),34.85%(23/66) and 18.18%(10/55) in group A,B and C respectively.The relapse rate in group A was obviously lower than that in group B(χ2 = 6.17,P < 0.05).Disease free interval in group A was significantly different from that in group B(F = 7.03,P < 0.05).Side effect in group A(12.28%) was observably lower than that in group B(43.94%) and group C(83.64%)(χ2AB = 15.72,P < 0.01;χ2AC = 55.34,P < 0.01).Conclusion:Perfusion of 10% brucea javanica oil after operation is safer and more effective in preventing superficial bladder tumour relapse and worth for popularizing. Objective: The aim of this study was to evaluate the effects and safety of brucea javanica oil, mitomycin and BCG for preventing postoperative relapse of superficial bladder cancer through perfusion. Methods: From July 2000 to May 2006 ,,178 patients with primary superficial bladder cancer ( Ta-1, G1-2) were divided into three groups after operation in random: 57 patients in group A received perfusion of 60 mL 10% brucea javanica oil, and 66 patients in group B received perfusion of 20 mg mitomycin while 55 patients in group C received perfusion of 120 mg BCG. Eighteen perfusions per patient were carried out regularly a week after operation. Patients were followed up for clinical, analytical and cystoscopic evaluations every 3 months for 2 years. tumor relapse rates and side effects after treatment were as follows. The relapse rates were 14.04% (8/57), 34.85% (23/66) and 18.18% (10/55) in group A, B and C respectively. The relapse rate in group A was obviously lower than than that in group B (χ2 = 6.17, P <0.05). Seido effect in group A (12.28%) was observably lower than that in group B (43.94%) and group C (83.64%) (χ2AB = 15.72, P <0.01; χ2AC = 55.34, P <0.01) .Conclusion: Perfusion of 10% brucea javanica oil after operation is safer and more effective in preventing superficial bladder tumor relapse and worth for popularizing.