目的研究长春瑞滨、顺铂联合(NP方案)治疗非霍奇金淋巴瘤的疗效及不良反应。方法长春瑞滨25mg/m2静脉注射,第1、8天,顺铂80mg/m2,静脉滴注第1～4天,21d为1个周期,2周期后评估疗效。结果有效率为72.1%,完全缓解率(CR)为27.9%,部分缓解率(PR)为34.2%,主要不良反应为:骨髓抑制:白细胞减少发生率为81.6%,便秘53.7%,其他不良反应少或轻微。结论NP方案治疗复发性非霍奇金淋巴瘤疗效好,不良反应轻,可作为复发非霍奇金淋巴瘤的二线治疗方案。 Objective To study the efficacy and adverse reactions of vinorelbine and cisplatin combination (NP regimen) in the treatment of non-Hodgkin’s lymphoma. Methods Vinorelbine 25mg / m2 intravenous injection, on the first and eighth days, cisplatin 80mg / m2, intravenous drip 1 to 4 days, 21d for a cycle, 2 weeks after the assessment of efficacy. Results The effective rate was 72.1%, the CR was 27.9% and the partial response rate was 34.2%. The main adverse reactions were: myelosuppression: the incidence of leukopenia was 81.6%, constipation was 53.7%, and other adverse reactions Less or slight. Conclusion The NP regimen is effective in treating recurrent non-Hodgkin’s lymphoma with mild adverse reactions and can be used as a second-line treatment for recurrent non-Hodgkin’s lymphoma.