论文部分内容阅读
近几年研究表明,成人外周血中含有与胚胎血管母细胞相似属性的骨髓源性细胞,它有分化为成熟内皮细胞的潜力,统称为内皮祖细胞(EPCs)。心肌缺血损伤后,EPCs能够归巢到心肌缺血区血管新生部位,促进其血管再生,而且它也能够分化为心肌细胞和平滑肌细胞。越来越多的实验和临床研究结果显示EPCs治疗冠心病安全可行,并且是有效的。现就EPCs的生物学特征及其在冠心病中的研究现状和面临的问题予以综述。
In recent years, studies have shown that adult human peripheral blood contains bone marrow-derived cells with similar properties as embryonic hemangioblasts and has the potential to differentiate into mature endothelial cells, collectively referred to as endothelial progenitor cells (EPCs). After myocardial ischemic injury, EPCs can homing to the angiogenesis site of the ischemic area of the myocardium to promote its angiogenesis, and it can also differentiate into cardiomyocytes and smooth muscle cells. A growing number of experimental and clinical studies have shown that EPCs are safe and feasible for the treatment of coronary heart disease and are effective. Now on the biological characteristics of EPCs and its research status and problems in coronary heart disease are reviewed.