布蚓佐胺(brinzolamide,商品名Azopt)是一种硫-噻嗪-6-磺胺碳酸酐酶抑制剂,其1％滴眼液已由美国FDA批准用于治疗开角型青光眼引起的眼内压增高。 它是FDA批准的第二种局部应用的碳酸酐酶抑制剂,此前批准的是多佐胺(dorzolamide) 药理学 布吲佐胺可被全身吸收,集中于红细胞中,但血药浓度通常维持在低水平(<7.5ng·ml~(-1))。约60％以原 Brinzolamide (Azopt), a thio-thiazine-6-sulfonic acid carbonic anhydrase inhibitor, has a 1% eye drop approved by the U.S. FDA for the treatment of open-angle glaucoma-induced intraocular Pressure increased. It is the second FDA-approved carbonic anhydrase inhibitor to be applied topically. Previously approved is dorzolamide pharmacology. Indazepine is absorbed systemically and is concentrated in erythrocytes, but the plasma concentration is usually maintained at Low level (<7.5ng · ml -1). About 60% of the original