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目的比较培氟沙星与左氧氟沙星治疗急性盆腔炎的疗效。方法确诊为急性盆腔炎患者84例,随机分入治疗组42例,静脉滴注培氟沙星加甲硝唑治疗;对照组42例,联合应用左氧氟沙星及甲硝唑治疗,疗程均为7～14d。观察用药疗效、细菌清除率及药物副反应。结果治疗组和对照组的治疗总效率分别为90.5%和73.8%,细菌清除率分别为82.4%和60.6%,不良反应发生率分别为16.7%和35.7%,差异均有统计学意义(P<0.05)。结论培氟沙星联合甲硝唑治疗急性盆腔炎治疗总效率高,安全性高、副反应较小,疗效优于左氧氟沙星及甲硝唑联合治疗,具有较高临床应用价值。
Objective To compare the efficacy of pefloxacin and levofloxacin in the treatment of acute pelvic inflammatory disease. Methods A total of 84 patients with acute pelvic inflammatory disease were randomly divided into treatment group (n = 42) and pefloxacin plus metronidazole. In the control group, 42 patients were treated with levofloxacin and metronidazole, and the course of treatment was 7 to 14 days . Observation of drug efficacy, bacterial clearance and drug side effects. Results The total effective rates of the treatment group and the control group were 90.5% and 73.8% respectively, the bacterial clearance rates were 82.4% and 60.6%, and the incidences of adverse reactions were 16.7% and 35.7%, respectively (all P < 0.05). Conclusion Pefloxacin combined with metronidazole in the treatment of acute pelvic inflammatory disease has the advantages of high total efficiency, high safety and less side effects, and is superior to levofloxacin and metronidazole in combination therapy, which has a high clinical value.