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氯丙嗪为苯駢噻嗪的衍生物,近几年来已在临床各科广泛应用。它的药理作用非常广泛,对中樞神經系統、植物神經系統、心血管系統和胃腸道机能均有抑制作用。苯駢噻嗪类药物抑制唾液分泌已早有报导,但其作用机制尚未完全明了,通常认为是由于它們的抗胆硷作用所致。近来有人报导氯丙嗪抑制胃液分泌与其中樞抑制作用有关。为了研究它对唾液分泌的抑制是否也有中樞作用的参与,我們利用唾液管瘻的犬
Chlorpromazine as benzothiazine derivatives, in recent years has been widely used in clinical subjects. It has a wide range of pharmacological actions and has an inhibitory effect on the central nervous system, autonomic nervous system, cardiovascular system and gastrointestinal tract. Phenothiazines inhibit salivary secretion has long been reported, but its mechanism of action is not yet fully understood, usually considered due to their anti-cholinergic effect. It has recently been reported that chlorpromazine inhibits gastric secretion and its central inhibitory effect. In order to investigate whether its inhibition of salivary secretion also has a central role in the participation, we used saliva fistula dogs