Background There is significant evidence showing that microalbuminuria and arterial compliance are sensitivemarkers for early cardiovascular diseases.However,whether microalbuminuria is associated with reduced arterialcompliance in Chinese metabolic syndrome(MS)patients remains unknown.Methods According to the definition of MS proposed by ATPⅢ in 2001,USA,subjects(n=362)were divided into threegroups according to the number of risk factors:group 1(control),group 2(medium,<3 risk factors)and group 3(MS,≥3 risk factors).Both large artery compliance(C1)and small artery compliance(C2)were measured with the CVProfilorDO-2020 Cardiovascular Profiling System,and microalbuminuria was evaluated with the ratio of albumin to urinecreatinine.Results(1)As C1 and C2 levels elasticity decreased,albumin creatinine ratio(ACR)and the prevalence ofmicroalbuminuria increased within those groups with MS risk factors.C1 and C2 were negatively correlated with theranking of MS risk factors,ACR was positively correlated with the ranking of MS risk factors(all P<0.05).(2)Subjectswere also categorized into a microalbuminuria group and a normal group,C1 and C2 in the microalbuminuria group werelower than in the normal group.(3)Multivariate regression analysis showed that increased systolic blood pressure(SBP)and reduced arterial compliance were the main risk factors for microalbuminuria in the MS group.Conclusions The risk of developing microalbuminuria was higher in the subjects with multiple metabolic abnormalities.Increased systolic blood pressure and reduced arterial compliance may be the main predictors for microalbuminuria inMS.Chin Med J 2007;120(16):1395-1399 Background There is significant evidence that that microalbuminuria and arterial compliance are sensitivemarkers for early cardiovascular diseases.However, whether microalbuminuria is associated with reduced arterial compliance (MS) patients remains unknown. Methods According to the definition of MS proposed by ATP III in 2001 , USA, subjects (n = 362) were divided into three groups according to the number of risk factors: group 1 (control), group 2 (medium, <3 risk factors) and group 3 large artery compliance (C1) and small artery compliance (C2) were measured with the CV Profile DrO-2020 Cardiovascular Profiling System, and microalbuminuria was evaluated with the ratio of albumin to urine creatine. Results (1) As C1 and C2 levels elasticity decreased, albumin creatinine ratio (ACR) and the prevalence of microalbuminuria increased within those groups with MS risk factors. C1 and C2 were negatively correlated with theranking of MS risk factors, ACR was positive (2) Subjectswere also categorized into a microalbuminuria group and a normal group, C1 and C2 in the microalbuminuria group werelower than in the normal group. (3) Multivariate regression analysis showed that increased systolic blood pressure (SBP) and reduced arterial compliance were the main risk factors for microalbuminuria in the MS group. Conclusions The risk of developing microalbuminuria was higher in the subjects with multiple metabolic abnormalities .creased systolic blood pressure and reduced arterial compliance may be the main predictors of microalbuminuria inMS. Chin Med J 2007; 120 (16): 1395-1399