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肾移植后的白细胞减少是临床上比较棘手的问题。以前缺乏有效的直接促使白细胞升高的办法。输白细胞又易导致移植物抗宿主(GVH)反应。最近,通过基因重组技术已获得了人粒细胞克隆刺激因子(G-CSF)。本文报告了应用G-CSF治疗肾移植后严重的白细胞减少的效果。 6例肾移植后白细胞减少的病人接受了G-CSF治疗。6例病人未梢血白细胞计数均低于2000/mm~3。有4例患者白细胞减少的原因为免疫抑制剂(主要是硫唑嘌呤)所致的骨髓抑制。1例是由于巨细胞病毒(CMV)感染。另1例是由上述两个原因共同引起的。在治疗上除停用硫唑嘌呤外,每天皮下注射G-CSF直到白细胞计数恢复。用量为2ug/kg/d,两例白细胞严重减少者用量为
Leukopenia after renal transplantation is a more clinically difficult problem. In the past, there was a lack of effective ways to directly promote leukocytosis. Leukocytes in turn lead to graft-versus-host (GVH) responses. Recently, human granulocyte colony stimulating factor (G-CSF) has been obtained by genetic recombination technology. This article reports the efficacy of G-CSF in treating severe leukopenia after renal transplantation. Six patients with leukopenia after renal transplantation received G-CSF. 6 cases of patients with peripheral blood leukocyte counts were lower than 2000 / mm ~ 3. The cause of leukopenia in 4 patients was myelosuppression due to immunosuppressive agents, mainly azathioprine. One case was due to cytomegalovirus (CMV) infection. Another case is caused by the above two reasons. In addition to the treatment of the withdrawal of azathioprine, daily subcutaneous G-CSF injection until white blood cell count recovery. The amount of 2ug / kg / d, two cases of severe reduction in white blood cell dosage