氟喹诺酮抗菌药已在世界范围内用于治疗严重感染。本文作者综述不同喹诺酮在吸收期的药物相互作用。主要讨论环丙沙星和氧氟沙星等与食物、H_2受体拮抗剂、抗胆碱能药物和含金属阳离子药物的相互作用。 食物(标准早餐)、H_2受体拮抗剂和抗胆碱能药物对喹诺酮药物的生物利用度无大的影响,但抗酸剂、硫酸亚铁和其他含金属阳离子的药物可降低喹诺酮的生物利用度。其机制是喹诺酮分子中的功能团与金属阳离 Fluoroquinolone antibacterials have been used worldwide to treat severe infections. The authors review the drug interactions of different quinolones during absorption. The main discussion of ciprofloxacin and ofloxacin and other food, H 2 receptor antagonist, anticholinergic drugs and metal-containing cationic drug interactions. Food (standard breakfast), H 2 receptor antagonists and anticholinergic drugs have no significant effect on the bioavailability of quinolones, but antacids, ferrous sulphate and other metal-cation containing drugs may reduce the bioavailability of quinolones degree. The mechanism is quinolone molecules in the functional groups and metal cation