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为了解门脉高压食管静脉曲张胃食管返流情况,采用24小时pH监测43例肝硬化食管静脉曲张患者食管pH动态变化,并对比出血组(25例)与未出血组(18例),发现:①门脉高压食管静脉曲张返流阳性率达628%(27/43)。②出血组(18/25)与未出血组(9/18)比较无显著差别(p<01)。③总返流次数出血组(40353±16250),明显多于无出血组(20410±19750)(p<005)。④长于5分钟返流次数:出血组(90±881),无出血组(48±265)两组比较(p<001)有显著性差异。⑤pH<400的总时间(分钟):出血组(37375±18570),无出血组(11325±8580),两组比较(p<005)。⑥不同静脉曲张程度的比较:重度曲张总返流次数明显多于中度曲张(p<005)。结论:①肝硬化门脉高压食管静脉曲张存在胃食管酸返流,且与静脉曲张程度呈正相关;②胃食管酸返流在食管静脉破裂出血中起重要作用
In order to understand the situation of gastroesophageal reflux in patients with esophageal varices, 24-hour pH was used to monitor esophageal pH in 43 cases of esophageal varices with cirrhosis and 25 cases with and without hemorrhage (18 cases) : ① The positive rate of portal hypertension in esophageal varices was 628% (27/43). ② There was no significant difference between bleeding group (18/25) and non-bleeding group (9/18) (p <01). ③ The total number of reflux was significantly higher in the bleeding group (40353 ± 16250) than in the non-bleeding group (20410 ± 19750) (p <005). ④ The number of reflux in longer than 5 minutes was significantly different between the two groups (p <001) in the bleeding group (90 ± 881) and no bleeding group (48 ± 265). ⑤pH <400 total time (minutes): bleeding group (37375 ± 18570), no bleeding group (113 25 ± 8580), the two groups (p <0 05). ⑥ Comparison of varicose veins: The total number of severe varices was significantly higher than that of moderate varices (p <005). Conclusions: ① There is gastroesophageal reflux in cirrhotic patients with portal hypertension and positive correlation with varicose veins; ② The gastroesophageal reflux disease plays an important role in the rupture of esophageal varices