近年来对细胞凋亡及其调控的广泛研究 ,促进了对B细胞发育及调节机制的理解。我们运用一系列转基因及基因剔除的鼠模型 ,研究了B细胞在各分化阶段的凋亡状况 ,发现一些基因具有调节B细胞发育、影响B细胞存活的功能。实验证明这些基因能通过影响Bcl 2家族蛋白的表达而决定细胞凋亡的阈值。有关领域的深入研究 ,将有助于理解人类淋巴系统肿瘤及自身免疫性疾病的发生机制 ,并为探索治疗这些疾病的新方法提供重要依据 In recent years, extensive research on apoptosis and its regulation has promoted the understanding of B cell development and regulation mechanism. We used a series of transgenic and knockout mouse models to study the apoptotic status of B cells at various stages of differentiation and found that some genes have the ability to regulate B cell development and affect B cell survival. Experiments show that these genes can affect the Bcl 2 family protein expression and determine the threshold of apoptosis. In-depth research in related fields will help understand the mechanism of tumor and autoimmune diseases in human lymphatic system and provide an important basis for exploring new methods for treating these diseases