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目的探讨尿邻甲酚作为接触甲苯生物监测指标的可能性。方法建立柱前衍生高效液相色谱法测定人体尿中邻甲酚,且使用该方法测定非职业及职业接触甲苯人群尿中邻甲酚水平,并进行接触评定。结果甲苯接触者尿邻甲酚水平为(2.61±1.94)mg/L,明显高于对照组[(0.32±0.23)mg/L],差异有显著性(P<0.001),且接触甲苯工人班后尿邻甲酚水平比班前明显升高,最高可达29倍。接触甲苯者尿邻甲酚水平与个体接触甲苯浓度明显相关(r=0.6295,P<0.01)。结论尿邻甲酚可以作为接触甲苯的生物监测指标。
OBJECTIVE To investigate the possibility of urinary o-cresol as a biological monitoring indicator of exposure to toluene. Methods The pre-column derivatization high performance liquid chromatography was established for the determination of o-cresol in human urine. The method was used to determine the urinary o-cresol level in non-occupational and occupational toluene inhalation patients and the contact assessment was conducted. Results The urinary o-cresol level in toluene-exposed patients was (2.61 ± 1.94) mg / L, which was significantly higher than that in the control group [(0.32 ± 0.23) mg / L] Post-urinary o-cresol levels were significantly higher than the class, up to 29 times. The level of urine o-cresol in contact with toluene was significantly correlated with the individual exposure to toluene (r = 0.6295, P <0.01). Conclusion Urinary o-cresol can be used as biological monitoring indicators of exposure to toluene.