The area that the railway will cross is a region with the main physiognomies of desert and Gobi, with a most fragile ecological environment. It is also a region that is highly susceptible to man-made disturbance. The construction of railway will intensify soil erosion along the railway line to a certain degree. The map of soil erosion conditions in the section from Liugou to Dunhuang City in the range of 10 km each side along the line was compiled by using the techniques of remote sensing and geographic information system (GIS). Based on analysis of the status of desertification and the influence of the railway construction projects, the changes of the types, intensities and the total amount of the soil erosion caused by the construction were predicted.