论文部分内容阅读
目的：探讨声脉冲辐射力成像技术（ARFI）中声触诊组织定量技术（VTQ）在甲状腺良、恶性结节鉴别诊断中的应用。方法选择山东大学齐鲁医院超声科2011年9月至2012年10月期间，经超声VTQ检测并手术或穿刺活检后病理证实的312个甲状腺结节（来自268例患者），据病理结果分为良性结节组（n＝196）和恶性结节组（n＝116），以相应的结节周围组织为良性结节周围组（n＝196）和恶性结节周围组（n＝116），对各组的VTQ检测结果进行回顾性分析并做统计学处理。结果①恶性结节组的VTQ测值显著高于其他3组（P＜0．001）；②良性结节组的VTQ测值与良性结节周围组、恶性结节周围组无显著差异（P＝0．174、P＝0．812、P＝0．063）。③据ROC曲线计算约登指数，确定界值3．25 m/s，为 ROC 曲线上的最佳临界点，对应的敏感度为89％，特异度为70％。结论超声VTQ技术对甲状腺良、恶性结节具有重要的鉴别诊断作用。“,”Objective To evaluate the diagnostic value of virtual touch tissue quantification (VTQ)of acoustic radia-tion force impulse (ARFI)elasticity imaging for differentiating benign from malignant thyroid lesions.Methods Two hundred and sixty-eight patients with 312 thyroid nodules undergoing thyroid nodules surgeryor biopsies after thyroid nodules VTQ examination were retrospectively reviewed.The patients were selected from the Department of Ultrasonog-raphy,Qilu Hospital of Shandong University,during Sep.201 1 to Oct.2012.All cases were divided into four groups, benign nodules group(n =196),parenchyma surrounding benign nodules group(n =196),malignant nodules group (n=116),and parenchyma surrounding malignant nodules group(n=116),according to the pathological results.The VTQ values of the four groups were detected and statistically analyzed.Results ①VTQ value of malignant thyroid nodules group was significantly higher than those of the other groups(P<0.001);②No significant difference was found among the VTQ values of parenchyma surrounding benign nodules group,benign nodules group and parenchyma sur-rounding malignant nodules group(P=0.174,P=0.812,P=0.063);③According to the receiver operating character-istic(ROC)curve,3.25 m/s was determined as the optimized point of the diagnostic value.When an SWV greater than 3.25 m/s was used for the diagnosis of malignant nodules and less than 3.25 m/s for the diagnosis of benign nod-ules,the sensitivity and specificity of ARFI imaging were 89%and 70%,respectively.Conclusion VTQ technology is more objective in quantitatively evaluating tissue hardness.VTQ technology shows better diagnostic value in the eval-uation of benign and malignant thyroid nodules.