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[目的]通过调查延边地区慢性丙型肝炎患者2型糖尿病患病率,探讨朝汉民族慢性丙型肝炎与2型糖尿病之间的关系。[方法]①367例慢性丙型肝炎(朝鲜族218例,汉族149例)、352例慢性乙型肝炎患者和681例健康体检者进行对照研究,明确其是否合并2型糖尿病。②用ELISA方法,对851例2型糖尿病患者及782例体检人群进行抗-HCV、HBsAg检测。[结果]①朝鲜族与汉族慢性丙肝患者2型糖尿病患病率为分别是24.31%,26.85%,差异无统计学意义(χ2=0.18,P﹥0.05);朝汉合并慢性丙肝患者2型糖尿病患病率为25.34%,慢性乙肝患者2型糖尿病患病率为9.38%,差异有统计学意义(χ2=18.36,P﹤0.01),与正常对照组2型糖尿病患病率9.84%进行比较差异也有统计学意义(χ2=36.60,P﹤0.01),慢性乙肝患者与正常对照组比较,2型糖尿病患病率差异无统计学意义(χ2=1.09,P﹥0.05)。②851例2型糖尿病患者中抗-HCV阳性72例(8.46%),HBsAg阳性33例(3.88%);782例体检人群中抗-HCV阳性23例(2.94%),HBsAg阳性78例(9.97%),两组抗-HCV阳性率、HBsAg阳性率差异均有统计学意义(P﹤0.01)。[结论]①慢性丙型肝炎患者易合并2型糖尿病,朝汉民族之间差异无统计学意义。②2型糖尿病患者中丙型肝炎病毒感染率高于普通人群,提示丙型肝炎病毒感染与糖尿病发生有一定关系。
[Objective] To investigate the relationship between type 2 diabetes and chronic hepatitis C in Han and Han ethnicity by investigating the prevalence of type 2 diabetes in patients with chronic hepatitis C in Yanbian area. [Methods] ①367 cases of chronic hepatitis C (218 cases of Korean and 149 cases of Han), 352 cases of chronic hepatitis B and 681 healthy subjects were compared to determine whether they had type 2 diabetes mellitus. ② ELISA method was used to detect anti-HCV and HBsAg in 851 patients with type 2 diabetes and 782 subjects. [Results] ①The prevalence of type 2 diabetes in Korean and Han patients with chronic hepatitis C were 24.31% and 26.85% respectively, with no significant difference (χ2 = 0.18, P> 0.05). The prevalence of type 2 diabetes in patients with chronic hepatitis C The prevalence of type 2 diabetes in patients with chronic hepatitis B was 9.38% with a prevalence of 25.34% (χ2 = 18.36, P <0.01), compared with 9.84% of the prevalence of type 2 diabetes in patients with chronic hepatitis B (Χ2 = 36.60, P <0.01). There was no significant difference in the prevalence of type 2 diabetes between chronic hepatitis B patients and normal controls (χ2 = 1.09, P> 0.05). Among the 851 type 2 diabetic patients, 72 (8.46%) were positive for anti-HCV and 33 (3.88%) were positive for HBsAg. Among the 782 subjects, 23 were positive for anti-HCV (2.94%), 78 were HBsAg positive (9.97% ), The positive rate of anti-HCV and the positive rate of HBsAg between the two groups were statistically significant (P <0.01). [Conclusion] ①Chronic hepatitis C patients are predisposed to type 2 diabetes mellitus, there is no significant difference between North Korea and China. ② Type 2 diabetes in patients with hepatitis C virus infection rate is higher than the general population, suggesting that hepatitis C virus infection and diabetes have a certain relationship.