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目的研究比较款冬花各个不同提取物对豚鼠离体回肠收缩的作用。方法通过石油醚、乙酸乙酯、CO2超临界萃取等方法制备款冬花多个提取物,将离体豚鼠回肠悬吊于克-亨试液中,观察给药后豚鼠回肠的收缩作用,计算豚鼠回肠收缩幅度抑制率。结果款冬花各个不同提取物均能降低组胺引起的豚鼠离体回肠收缩幅度。结论款冬花各个提取物能明显抑制豚鼠回肠收缩运动。
Objective To study the effect of different extracts of Coltsfoot on the ileum contraction of guinea pigs. Methods Several extracts of Coltsfoot were prepared by petroleum ether, ethyl acetate, and CO2 supercritical fluid extraction. Guinea pig guinea pigs were suspended from the ileum in Ke-Heng test solution. The guinea pig ileum contraction was observed after administration and the guinea pigs were calculated. Ileum contraction amplitude inhibition rate. Results The different extracts of Coltsfoot flower could reduce the extent of histamine-induced ileum contraction in guinea pigs. Conclusion Each extract of Coltsfoot can significantly inhibit the ileum contraction of guinea pigs.