作者观察到3例患者血清结合珠蛋白的明显升高与胆囊癌相关。这有助于胆囊癌的早期诊断,以免不必要的外科探查。例1:女,69岁。因腹痛及上腹饱张入院。体检右上腹压痛,肝于剑突下4cm 可扪及。由于胆囊造影不显影拟诊急性胆囊炎行剖腹探查。术中发现为中度分化的胆囊腺癌并有肝转移,未作肿瘤切除。术后2周用放射免疫扩散法测得其血清结合珠蛋白为830mg/dl(正常60～220mg/dl),用放疗和5-Fu 治疗。术后15周患者死亡,死前血清结合珠蛋白降为660mg/dl。例2:女,51岁。因右上腹痛、体重减轻及黄疸入院。体检:肝于右肋下12cm 可扪及,结节状,质硬。腹腔镜肝活检诊为低分化的转移腺癌,原发灶可 The authors observed a significant increase in serum haptoglobin in 3 patients associated with gallbladder cancer. This helps early diagnosis of gallbladder cancer to avoid unnecessary surgical exploration. Example 1: Female, 69 years old. He was admitted to the hospital due to abdominal pain and epigastric fullness. Physical examination of the right upper quadrant tenderness, liver 4cm below the xiphoid can be palpable. As the cholecystography does not reveal the diagnosis of acute cholecystitis laparotomy. Intraoperative findings were moderately differentiated gallbladder adenocarcinoma with hepatic metastases and no tumor resection. Serum conjugated globin was measured at 830 mg/dl (normally 60-220 mg/dl) 2 weeks after radioimmunoassay and treated with radiotherapy and 5-Fu. At 15 weeks postoperatively, the patient died. Pre-death serum haptoglobin was reduced to 660 mg/dl. Example 2: Female, 51 years old. Due to right upper abdominal pain, weight loss, and jaundice admitted to hospital. Physical examination: The liver is 12cm under the right ribs, palpable, nodular and hard. Laparoscopic liver biopsy for poorly differentiated metastatic adenocarcinoma